RESEARCH & DEVELOPMENT

Complementary to the contract research services, Bionos participates in various R&D projects in collaboration with national and international companies and public institutions.

H2020 – AlgaeCeuticals (Marie Sklodowska-Curie actions)

Microalgae biomass represents a rich source for discovery. The potential for algae-based ingredients in the industry relies on the manipulation and targeting of ingredients to fit increasingly niche product specifications. Algae are exposed to extreme environment and thus have developed unique mechanism for protection. Furthermore, algae produce for the same reason different metabolites which we need to identify and exploit in a sustainable way for the production of food, drugs and cosmetics.
The AlgaeCeuticals project will take advantage of the native algae strains producing high added value products and through the application of novel omics technologies (genomics, transcriptomics, proteomics, enzymomics and metabolomics) as well as algae culture technologies and production of novel products. AlgaeCeuticals will screen and characterize algae biodiversity, develop and optimize algae culture systems, develop omics resources for algae and also develop downstream processing strategies and also develop novel products.

Referencia: 778263
https://cordis.europa.eu/project/rcn/213018_es.html

H2020 – Phocnosis

The PHOCNOSIS project aims at the development and the preclinical validation of a nanotechnology-based handheld point-of-care testing (POCT) analysis device for its application in the early diagnosis of cardiovascular diseases (CVD). This POCT analysis device will significantly help in the implementation of mass screening programs, with the consequent impact on clinical management, reducing also costs of treatments, and increasing survival rates.

Reference: H2020-PHC-634013
https://cordis.europa.eu/project/rcn/193268_es.html

Universidad de Valencia – ICMOL

In collaboration with the Molecular Science Institute (ICMOL) from the University of Valencia, Bionos develops efficacy and functionality assays to validate the activity of new chemical entities, in order to market them as new products for the cosmetic and pharmaceutical industries.

The Institute of Molecular Science (ICMol), located at the Parc Cientific de la Universitat de València, was founded in 2000 and is recognized internationally as one of the pioneering centres for the research on molecular science. The ICMol employs more than 100 scientific researchers and houses the most advanced systems for the preparation, characterization and study of molecules and molecular materials. In the Centre, potential application of molecules and materials are explored, in different areas of current interest (molecular magnetism, molecular electronics, nanotechnology, biotechnology, catalysis, etc.).

Proyecto INNTAL 31/19/007 – Innodocto – AVI

Bionos Biotech, S.L. has received a grant for the project “Development of Screening Platforms for Drugs against Huntington’s Disease” with file number INNTAL 31/19/007, through the Talent Promotion Program / L3. Emphasial PhD students (Innodocto) of the Valencian Agency of Innovation (AVI). The grant for this project is €30,153.92.

This grant allows the formation of a PhD in Bionos Biotech, S.L., promoting the acquisition of the necessary skills to develop R&D projects in business environments and thus increase the degree of technification and innovative capacity of the company’s workforce. Specifically, the objective of the project is the research and development of screening platforms for the identification of compounds with therapeutic potential for Huntington’s disease (HD), which is part of Bionos’ long-term R&D strategy Biotech, of neurodegenerative diseases in general.

IUCT-Inkemia

Bionos and IUCT-Inkemia through a Joint Venture project collaborate in the development of new functional ingredients for the cosmetic market. Bionos contributes its know-how and efficacy assays to validate the activity of new compounds, whereas Inkemia contributes with a library of bioactive compounds, obtained from remote places with special environmental conditions.

Inkemia’s mission is the generation, management and exploitation of knowledge of high technological value. The business base of Inkemia is the generation of knowledge, which is exploited through the promotion and sale of high value products and services for the chemical, food, pharmaceutical, biopharmaceutical and biotechnology fields.

Medical Research Institute Hospital La Fe (IIS La Fe)

Bionos collaborates in various projects with several research groups and services from Medical Research Institute Hospital La Fe. Through them, Bionos is in direct contact with doctors and researchers, allowing to meet the existing needs in the different medical fields and events that take place in a European pointer clinical and scientific environment.

The IIS La Fe is the area of biomedical research created between the University Hospital and Polytechnic La Fe, the University of Valencia, the Polytechnic University of Valencia, the Higher Council for Scientific Research (CSIC) and the Research Foundation of the La Fe Hospital from Valencian Community. The institute fosters and promotes excellence research, scientific and technological knowledge and its subsequent translation to the industry, as well as teaching and training. Re-accredited in 2014 by the Carlos III Health Institute, it is composed of 28 accredited research groups, 12 mixed units and other research groups.

ITTUTE/2019/37 project

PROJECT: ITTUTE/2019/37 – Bionos Biotech – Grant for the Check Internationalization Tutorials (Advice to companies 2019)

The main objective of this aid is to improve th strategy of sMEs in the Valencian Community in the different areas of internationalization and this, gain a competitive position in foreign markets through intensive, highly specialized and individualized support.

The project has had the help of IVACE within the program Bionos Biotech – Grant for the Check Internationalization Tutorials (Advice to companies 2019), with a grant of 2.520,00 €, with funding from the European Regional Development Fund (ERDF), through the ERDF Operational Program of the Valencian Region 2014-2020.

ITATUT/2019/40 project

PROJECT: ITATUT/2019/40 – Bionos Biotech – Grant for the follow-up plans of the Internationalization Tutoring Programs of Pymes in the C.V. 2019

The main objective of this aid is the definition and implementation of the bases that form the Strategic Plan of Internationalization of services (PEI) of the company Bionos Biotech SL, throughout the year 2019, according to the objectives and strategies treated in the Internationalization Tutoring Programs 2016.

The project has had the help of IVACE within the program Bionos Biotech – Grant for the follow-up plans of the Internationalization Tutoring Programs of Pymes in the C.V 2018, with a grant of 17.288,58 €, with funding from the European Regional Development Fund (ERDF), through the ERDF Operational Program of the Valencian Region 2014-2020.

ITATUT/2021/25 project

PROJECT: ITATUT/2021/25 – Bionos Biotech – Grant for the follow-up plans of the Internationalization Tutoring Programs of Pymes in the C.V. 2021

The main objective of this aid is the definition and implementation of the bases that form the Strategic Plan of Internationalization of services (PEI) of the company Bionos Biotech SL, throughout the year 2021, according to the objectives and strategies treated in the Internationalization Tutoring Programs 2016.

The project has had the help of IVACE within the program Bionos Biotech – Grant for the follow-up plans of the Internationalization Tutoring Programs of Pymes in the C.V 2021, with a grant of 10.507,50 € €, with funding from the European Regional Development Fund (ERDF), through the ERDF Operational Program of the Valencian Region 2014-2020.

IMIDTA /2018/79 project

PROJECT: IMIDTA/2018/79 – “Development of screening platforms for drugs targeting Huntington’s disease”.

The main goal of the present project (HUNTINGFISH) is the reserach and development of screening platforms to identify compounds with therapeutic potential for Huntington’s disease (HD) according to the company’s objectives and long-term R&D strategies, in global neurodegenerative diseases.

The project has had the help of IVACE within the program “R&D PYME projects (PIDI-CV)”, with a grant of 31.622 €, with funding from the European Regional Development Fund (ERDF) in 50 %, through the ERDF Operational Program of the Valencian Region 2014-2020.

ITAPIN/2018/24 project

PROJECT: ITAPIN/2018/24 – Bionos Biotech – Grant for the follow-up plans of the Internationalization Tutoring Programs of Pymes in the C.V.

The main objective of this aid is the definition and implementation of the bases that form the Strategic Plan of Internationalization of services (PEI) of the company Bionos Biotech SL, throughout the year 2018, according to the objectives and strategies treated in the Internationalization Tutoring Programs 2016.

The project has had the help of IVACE within the program Bionos Biotech – Grant for the follow-up plans of the Internationalization Tutoring Programs of Pymes in the C.V 2018, with a grant of 11.029,38 €, with funding from the European Regional Development Fund (ERDF), through the ERDF Operational Program of the Valencian Region 2014-2020.

ITAPIN/2017/570 project

PROJECT: ITAPIN/2017/570 – “Internationalization Strategic Plan“.

The main objective of this aid is the preparation of the Internationalization Strategic Plan of the Bionos’ R&D services. The project has had the help of IVACE within the program HELP TO THE INTERNATIONALIZATION PLAN OF THE VALENCIA COMMUNITY PYMES (2017) with a grant of 2.816,25 €, with funding from the European Regional Development Fund (ERDF), through the ERDF Operational Program of the Valencian Region 2014-2020.

IMAPEA/2016/43 project

PROJECT: IMAPEA / 2016/43 – “New drug based on SOD-enzymes for the treatment of neurodegenerative diseases”.

The main objective of this aid is the preparation of proposals for the participation of BIONOS in the call SME INSTRUMENT-Phase I. The project has had the help of IVACE within the program PREPARATION OF PROPOSALS FOR CALLS H2020 with a grant of 3,542.50 €, with funding from the European Regional Development Fund (ERDF), in a percentage of 50%, through the ERDF Operational Program of the Valencian Region 2014-2020.

EMP-FPSG/2016/5195 project

PROJECT: EMP-FPSG-2016-5195 – “Development and preclinical validation of a portable point-of-care (POC) analysis device”.

The main objective of this aid is the to foster de development of R&D activities and the creation of employment and quality, through hiring a graduate in professional training (FP) to carry out the development and preclinical validation of a portable point-of-care (POC) analysis device, based in various novel nanotechnological concepts for its application in the early diagnosis of cardiovascular diseases. This aid is financed by the State Agency for Research (Ministry of Economy, Industry and Competitiveness) and the State Program for the Promotion of Talent and its Employability, included in the State Plan for Scientific, Technical and Innovation Research 2013-2016.

ALOSTOP RTC2019-007035-1 project

PROJECT: ALOSTOP RTC2019-007035-1 “Development of new nanotechnological therapies for follicular release applied to alopecia.”

The main objective of the project is to bring to an exploratory clinical study an innovative treatment more effective than the current ones for the treatment of alopecia. The participants in this project are: Laboratorio Reig Jofre S.A., Fundación para la investigación biomédica del Hospital Univ. Ramon y Cajal, Fundación Bosch i Gimpera and Bionos Biotech.

This project has been funded by the Ministry of Science and Innovation within the RETOS-COLABORACIÓN Subprogram, Call 2019. The project is co-funded by the European Union with the aim of promoting technological development, innovation and quality research.

Proyecto HUNTINGTON – INNTA3/2021/26 (AVI)

HUNTINGTON’S DISEASE DRUG SCREENING PLATFORM DEVELOPMENT PROJECT.

Project co-financed by the European Union through the Operational Program of the European Regional Development Fund (ERDF) of the Valencian Community 2014- 2020.

Bionos Biotech, S.L. has received a grant for its project “Development of Screening Platforms for Huntington’s Disease Drugs” with file number INNTA3/2021/26, through the Talent Promotion program / L3. Entrepreneurial doctoral students (Innodocto) of the Valencian Innovation Agency (AVI).

This grant allows the training of a PhD student at Bionos Biotech, S.L., providing the necessary skills to develop R&D projects in business environments and thus increase the degree of technification and innovative capacity of the company’s staff. Specifically, the objective of the project is the research and development of screening platforms for the identification of compounds with therapeutic potential for Huntington’s disease (HD), which is part of Bionos Biotech’s long-term R&D strategy for neurodegenerative diseases in general.

H2020 – CypTox (Marie Sklodowska-Curie actions)

With the need to sustainably control major agricultural pests and vectors, it is imperative to develop new effective insecticides with excellent environmental profiles. To achieve this goal, the overall objective of the CypTox project is to exploit the main P450-based metabolic pathway of the organisms of interest for the development of highly selective and safe insecticides and new formulations that prevent the generation of resistance, in order to improve the efficiency and sustainability of pests and vectors.

Reference: 101007917
https://cordis.europa.eu/project/id/101007917

Proyecto OGMIOS – INNEST2021-56 (AVI)

PROJECT: INNEST2021-56 – Bionos Biotech – Cooperative Strategic Projects (OGMIOS Project)

The objective of the OGMIOS project is the design and development of an intelligent decision support system in the field of genomic clinical diagnosis, specifically in the field of genetic predisposition to pediatric cancer and cardiovascular diseases (familial heart disease with risk of sudden death). The proposed solution is based on the analysis of the technological problems posed by the real implementation of an effective Precision Medicine (PM), with the aim of creating an intelligent information system to assist the clinical expert in the diagnostic process, covering all stages of genetic diagnosis and enabling its integration into daily clinical practice.

As a result of the development of this project, a technology destined to become an essential part of the clinical diagnostic process will be obtained, allowing to position the Valencian Community as a reference in the diagnosis and personalized treatment of quality in children’s oncology and cardiovascular medicine. This technology can be applied and exploited in other clinical and industrial environments (e.g. agri-food).

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